Jonathan Trent | Medicine and Health Sciences | Lifetime achievement Award

Published on by Research Hypothesis

Jonathan Trent | Medicine and Health Sciences | Lifetime achievement Award

Prof. Dr Jonathan Trent, Sylvester Comprehensive Cancer Center, University of Miami, United States

Prof. Dr. Jonathan Trent is a distinguished oncologist and researcher, specializing in sarcoma and precision medicine. With an MD and PhD from The University of Texas Health Science Center, he has dedicated his career to advancing cancer treatment. As Associate Director of Clinical Research at Sylvester Comprehensive Cancer Center, he leads groundbreaking studies in medical oncology. His leadership in precision medicine has transformed sarcoma treatment strategies. A prolific author, he has contributed to numerous high-impact publications, shaping the future of cancer therapy. Recognized for his mentorship and excellence in patient care, he has received prestigious awards like Sylvester Outstanding Mentor of the Year. His commitment to clinical innovation and translational research continues to impact oncology worldwide.

Publication Profile

Scopus

Education

Prof. Dr. Jonathan Trent earned his BS in 1988 from Southeastern Oklahoma State University, Durant, OK. He then pursued an MD-PhD program at The University of Texas Health Science Center, Houston, TX (1988-1995), where he developed expertise in oncology and medical research. His postgraduate training includes a Clinical Internship (1995-1996) and a Clinical Residency (1997-1999) at the same institution. He further specialized in cancer treatment through a Medical Oncology Fellowship at MD Anderson Cancer Center (1999-2002), where he also served as Chief Fellow. His extensive academic training laid a strong foundation for his groundbreaking research in sarcoma and precision medicine.

Experience

Prof. Dr. Jonathan Trent began his academic career as Assistant Professor (2002-2008) and later Associate Professor (2008-2011) at MD Anderson Cancer Center. He also served as an Adjunct Professor (2014-2015) at its Graduate School of Biomedical Sciences. Since 2013, he has been a Professor of Medicine at the University of Miami, where he is also Associate Director of Clinical Research, Director of the Sarcoma Medical Research Program, and Director of Precision Medicine at Sylvester Comprehensive Cancer Center. His leadership in sarcoma research, clinical trials, and precision oncology has significantly advanced cancer treatment.

Awards and Honors

Prof. Dr. Jonathan Trent has received numerous prestigious awards for his contributions to oncology, including the Sylvester Outstanding Mentor of the Year 🏆 (Miller School of Medicine, 2015), the Outstanding Care Award 🏅 (Sarcoma Alliance, 2012), and the Leadership in Clinical Research 🎖️ (Sylvester Comprehensive Cancer Center). He is an esteemed member of elite professional organizations such as the American Society for Clinical Oncology (ASCO), the American Association of Cancer Research (AACR), and The Max Foundation. His dedication to oncology research and patient care has earned him national and international recognition.

Research Focus

Prof. Dr. Jonathan Trent’s research focuses on sarcoma, targeted therapies, and precision oncology. He has played a pivotal role in the development of novel therapies, including TRK fusion inhibitors, CDK7-targeted treatments, and IDH1 mutation-based interventions. His work has significantly improved the understanding of leiomyosarcoma, chondrosarcoma, and desmoid tumors. As Director of Sarcoma Medical Research and Precision Medicine at Sylvester Comprehensive Cancer Center, he integrates genomic profiling and personalized treatment strategies to enhance patient outcomes. His extensive clinical trials and translational research have shaped modern sarcoma therapies, contributing to groundbreaking advancements in oncology.

Publication Top Notes

A Phase I Study of FHD-609, a Heterobifunctional Degrader of Bromodomain-Containing Protein 9, in Patients with Advanced Synovial Sarcoma or SMARCB1-Deficient Tumors

Gastrointestinal Stromal Tumor Patients with Molecular Testing Exhibit Superior Survival Compared to Patients without Testing: Results from the Life Raft Group (LRG) Registry

Beyond the Driver Mutation: Immunotherapies in Gastrointestinal Stromal Tumors

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

Notch pathway inhibition with LY3039478 in soft tissue sarcoma and gastrointestinal stromal tumours

Use of tyrosine kinase inhibitors in patients with GI stromal tumor who are pregnant or considering pregnancy: Driver mutations and circulating tumor DNA

Limb-sparing surgery plus radiotherapy results in superior survival: an analysis of patients with high-grade, extremity soft-tissue sarcoma from the NCDB and SEER

JAYALEKSHMI C | Medical Hypotheses | Best Researcher Award

Published on by Research Hypothesis

JAYALEKSHMI C | Medical Hypotheses | Best Researcher Award

Mrs JAYALEKSHMI C, Department of Biotechnology, PSG College of Arts & Science, Coimbatore, Tamilnadu, India

Mrs. Jayalekshmi C is a dedicated researcher pursuing a Ph.D. in Biotechnology at Bharathiar University, focusing on innovative applications of biological sciences. She holds an M.Sc. in Biotechnology from RVS College of Arts & Science (2007) and a B.Sc. in Biotechnology from Bishop Moore College (2005), both with distinction. Her expertise spans microbiology, molecular biology, genetic engineering, and advanced biotechnological techniques like PCR, SDS-PAGE, and DNA purification. She has contributed to impactful research, including publications on Calotropis gigantea-based cancer treatments and zinc oxide nanoparticles. Mrs. Jayalekshmi actively participates in national conferences and webinars, sharing her passion for advancing science. 🌱🔬📚✨

Publication Profile

orcid

Academic Record 

Mrs. Jayalekshmi C is a dedicated scholar in the field of biotechnology. She is currently pursuing a Ph.D. in Biotechnology at Bharathiar University, P.S.G. College of Arts and Science (2017–present) 🧪📚. She holds an M.Sc. in Biotechnology (2007) from RVS College of Arts and Science, Bharathiar University, with a commendable 75% 🧬🎓. Her academic foundation includes a B.Sc. in Biotechnology (2005) from Bishop Moore College, Kerala University, also achieved with 75% 🥼📖. Jayalekshmi excelled in her Plus Two (HSE) at N.S.H.S.S. Mannar with 79% (2002) 🏅📘 and completed her S.S.L.C. at S.B.E.M.H.S. Mannar with 75% (2000) 📜🌟.

Theoretical and Practical Knowledge

Mrs. Jayalekshmi C is a skilled researcher with expertise in microbiology 🦠, biochemistry 🧪, molecular biology 🔬, and genetic engineering 🧬. Proficient in advanced techniques such as SDS-PAGE, PCR, Southern and Western blotting, and ELISA 📊, she excels in isolating and purifying genomic DNA from plants and microorganisms 🌱🧫, as well as plasmid and lambda phage DNA. Her work reflects a deep understanding of cell biology, genetics, and recombinant DNA technology, making her a valuable contributor to scientific advancements in these fields. Her dedication to research and innovation drives impactful outcomes in molecular sciences. 🌟

Research Experience 

Mrs. Jayalekshmi C has made significant contributions to biology through diverse projects. She has explored cutting-edge cancer research techniques, showcasing her dedication to advancing medical science. Her work on penicillin production and bacterial sensitivity highlights her innovative approach to microbiology, addressing real-world health challenges. With a keen ability to tackle complex biological problems, Mrs. Jayalekshmi combines scientific rigor with creativity, pushing the boundaries of knowledge. Her efforts underline a commitment to fostering innovation and solutions in biotechnology, reflecting a passion for impactful research and discovery. 🌟🔬🧫💡

Research Focus

Jayalekshmi C’s research focuses on nanotechnology and bioactive compounds for therapeutic applications. Her work includes biosynthesis and characterization of zinc oxide nanoparticles derived from Calotropis gigantea latex, emphasizing sustainable methods 🌱🔬. She investigates these nanoparticles’ biofunctional roles, including their anticancer potential and broader biomedical applications 🧬💊. Additionally, her research explores Calotropis gigantea’s bioactive compounds for innovative cancer treatments, combining natural resources with cutting-edge technology to enhance healthcare solutions 🩺🌿. This interdisciplinary approach blends biotechnology, materials science, and medicine, contributing to environmentally friendly nanomaterials and advancing cancer therapies for societal benefit 🌍✨.

Training and Participation 

Mrs. Jayalekshmi C is a committed professional, actively participating in workshops, webinars, and national conferences to enhance her expertise and stay current in her field. Her dedication to professional growth reflects her passion for continuous learning and staying abreast of the latest advancements. Through these engagements, she has gained valuable insights, broadened her knowledge, and fostered meaningful connections with peers and experts. Her proactive approach to self-improvement underscores her drive for excellence and her commitment to making a positive impact in her profession. 🌟📚🤝✨

Publication Top Notes

Calotropis Gigantea Latex-Derived Zinc Oxide Nanoparticles: Biosynthesis, Characterization, and Biofunctional Applications

Bioactive compounds of Calotropis gigantea for cancer treatment

Conclusion 

With a robust academic background, extensive practical expertise, and impactful research in biotechnology, Mrs. Jayalekshmi C is a deserving candidate for the “Research for Best Researcher Award.” Her contributions, particularly in cancer treatment innovations and nanotechnology applications, underline her potential for future breakthroughs in the field.