Denise Faustman | Medicine and Health Sciences | Best Researcher Award

Dr. Denise Faustman | Medicine and Health Sciences | Best Researcher Award

Direcotr of immunobiology laboratory | washington university school of medicine | United States

Dr. Denise Faustman is a physician-scientist whose career exquisitely bridges clinical medicine, immunology, and translational research. She earned her Ph.D. in Molecular and Cellular Biology along with her M.D. in Medicine from Washington University School of Medicine, and she holds a bachelor’s degree in Zoology & Chemistry from the University of Michigan. Over her professional journey, Dr. Faustman has held roles such as Director of the Immunobiology Laboratory at Massachusetts General Hospital and Associate Professor of Medicine at Harvard Medical School, and she continues to lead efforts in immunotherapy, autoimmunity, and metabolic modulation. Her research interests center on autoimmune disease mechanisms, autoreactive T cells, the immunoregulatory role of TNF/TNFR2, use of Bacillus Calmette–Guérin (BCG) vaccine in type 1 diabetes, epigenetic modulation of immune cells, and the intersection of immunometabolism and regenerative therapies. Her technical and methodological skills span immunology assays (flow cytometry, T-cell functional assays, cytokine profiling), epigenetic and methylation analyses, transcriptomics, metabolomics, clinical trial design, and translational biomarker development. In her career she has authored 115 documents, has accrued 5,972 citations, and holds an h-index of 42, attesting to her sustained academic influence. Professionally, Dr. Faustman has led multiple NIH-funded and translational projects, engaged in global advisory committees (including in immunology, diabetes, and regulatory policy), and established collaborations across institutions in North America and Europe. She has served on scientific advisory boards, chaired expert panels, participated in FDA and NIH review committees, and mentored many early-career scientists. Her honors include recognition for contributions to autoimmune disease research, invitations as plenary or keynote speaker at international conferences, and appointments to leadership roles in professional societies and advisory bodies. In summary, Dr. Denise Faustman combines deep scientific insight, rigorous methodological skill, leadership in translational immunology, and a track record of high-impact publications to make significant contributions both to fundamental immunology and to treatments for type 1 diabetes and other autoimmune diseases. She is well positioned to continue driving innovation in immunotherapy, to mentor the next generation of biomedical scientists, and to lead large-scale international collaborative projects that translate immunological discoveries into patient benefit.

Profile: ORCID | Scopus

Featured Publications

  1. Faustman, D. L. (2001). Reversal of established autoimmune diabetes by restoration of endogenous beta cell function. Journal of Clinical Investigation.

  2. Kodama, S., Kuhtreiber, W., Fujimura, S., Dale, E. A., & Faustman, D. L. (2003). Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science.

  3. Kühtreiber, W. M., Tran, L., Kim, T., Dybala, M., Nguyen, B., Plager, S., Huang, D., Janes, S., Defusco, A., Baum, D., Zheng, H., & Faustman, D. L. (2018). Long-term reduction in hyperglycemia in advanced type 1 diabetes: the value of induced aerobic glycolysis with BCG vaccinations.

  4. Kuhtreiber, W. M., et al. (2023). BCG clinical trial programs in advanced type 1 diabetes.

  5. Faustman, D. L., Davis, M. (2013). TNF receptor 2 and disease: autoimmunity and regenerative medicine.

 

ALI KAISSI | Medicine and Health Sciences | Excellence in Research Award

ALI KAISSI | Medicine and Health Sciences | Excellence in Research Award

Prof. Dr ALI KAISSI, orthopaedic Hospital Speising Vienna, Austria

Dr. Ali Al Kaissi is a distinguished medical scientist and consultant in pediatric orthopedics with an illustrious international career spanning over four decades. A graduate of Al-Azhar University, Cairo, he pursued postgraduate training and specialization in the United Kingdom, Tunisia, Austria, and Russia. He is best known for his groundbreaking contributions to pediatric skeletal dysplasias and genetic disorders, including the identification of Al Kaissi syndrome (OMIM 617694). As an honorary professor and senior researcher, he has collaborated with prestigious institutions such as the Turner Orthopedic Institute (Russia), Ilizarov Institute (Kurgan), and the University of Saskatchewan (Canada). Dr. Al Kaissi’s multidisciplinary expertise and diagnostic acumen have contributed to the understanding of complex orthopedic and craniofacial disorders. His global impact is reflected through his numerous publications, awards, and honorary appointments.

Publication Profile

Scopus

Education

Dr. Al Kaissi received his foundational medical degree from Al-Azhar University, Cairo (1978). He continued his postgraduate education in the United Kingdom, earning a Certificate in Pediatrics (1988), followed by a Master’s degree in Pediatric Developmental Abnormalities from the University of Warwick (1990). His academic excellence was later recognized with a Doctor of Science (Honorary) from the Turner Scientific Research Institute for Children’s Orthopedics in Saint Petersburg, Russia (2017). His educational path reveals a strong emphasis on pediatric orthopedics, developmental abnormalities, and rare syndromic disorders. His continuous pursuit of medical education, coupled with his pioneering research, has laid the foundation for significant clinical contributions and novel diagnostic insights into congenital and acquired musculoskeletal diseases.

Experience

Dr. Al Kaissi has held numerous high-level clinical and research positions internationally. Since 2005, he has served as a consultant and scientist at the Orthopedic Hospital of Speising in Vienna, Austria. Previously, he led pediatric orthopedic clinical research at the Children’s Hospital in Tunis, Tunisia (1993–2005), where he also established a national center for early recognition of congenital malformation complexes. He has been involved in key medical posts in Iraq, the UK, and Russia, spanning from senior house officer roles to visiting professorships. His experience encompasses both the clinical management of pediatric orthopedic conditions and pioneering research into rare skeletal dysplasias and syndromes. His extensive global collaborations and ability to identify novel pathologies have positioned him as a leader in diagnostic orthopedic research.

Awards and Honors

Dr. Al Kaissi has been the recipient of numerous international awards recognizing his excellence in clinical research and diagnostics. He received the prestigious Russian Golden Medal for Distinguished Clinicians and the Silver Dagestani Sword in 2019. In 2017, he was conferred an Honorary Doctorate (DSc) from the Turner Pediatric Orthopedic Institute, Russia. His contributions have been acknowledged by ministries of health in Russia and Tunisia, among others. He holds honorary professorships at premier Russian institutions including the Ilizarov Institute and the Pediatric Kidney Clinic of Dagestan. His honors reflect not only individual achievement but also the broader impact of his diagnostic innovations on pediatric care and genetic research.

Research Focus

Dr. Al Kaissi’s research focuses on pediatric skeletal dysplasias, craniofacial anomalies, syndromic disorders, and orthopedic genetics. He has discovered and characterized several new syndromes including “Al Kaissi syndrome” (OMIM 617694) and contributed to the understanding of 3MC syndrome and Desbuquois dysplasia-like conditions. His diagnostic insights into wormian bones and thoracic collapse disorders have redefined clinical approaches in developmental orthopedics. His collaboration with environmental scientists has broadened his scope to ecotoxicology and skeletal pathology in wildlife exposed to toxins, reflecting a unique intersection between human and environmental health. His publications cover radiographic and tomographic evaluations, syndrome delineation, and the interplay of environmental exposures with skeletal disease. His work continues to shape diagnostic criteria and management protocols globally.

Publication Top Notes

  • Al Kaissi Syndrome – OMIM (617694): Identified a novel syndrome with growth retardation, spinal malformation, and dysmorphic facies.

  • 3MC Syndrome with Baraitser – OMIM (257920): Defined craniofacial and skeletal anomalies in conjunction with Michael Baraitser.

  • “Progressive Collapse of the Thoracic Cage” – American Journal of Medicine, 2017.

  • “Novel Conception of Wormian Bones” – Diagnostics Journal, 2023.

  • “Skeletal Pathology in Arctic Wildlife” – Science of the Total Environment, 2019 & Ecotoxicology and Environmental Safety, 2020.

  • “Meticulous and Early Understanding of Cranial Defects Can Save Lives” – Children, 2023.

  • “Craniofacial Malformations in Syndromic Entities” – Diagnostics, 2022.

  • “Arthrogryposis and Escobar Syndrome” – Minerva Pediatrics, 2024.

  • “Non-lethal ZMPSTE24 Mutation in Progeria” – Clinical Genetics, 2023.