Prof Jim Sheu, National Sun Yatsen University, Taiwan
Prof. Jim Sheu is a distinguished biomedical scientist with over two decades of academic and research excellence in life sciences. Holding a Ph.D. in Life Science from National Tsing-Hua University (2002), he has consistently advanced the frontiers of molecular oncology, stem cell therapy, and women’s reproductive health. Currently a professor at National Sun Yat-sen University, Taiwan, he has previously held prestigious research and academic positions at China Medical University and Johns Hopkins Medical Institutions. He is widely recognized for his role in leading innovative biomedical projects and mentoring the next generation of scientists. Prof. Sheu has made pioneering contributions to cancer genomics, glioblastoma therapeutics, and endometriosis research. His prolific publication record and multiple awards underline his leadership and innovation in the field. His work bridges translational research with clinical applications, shaping modern therapeutic strategies.
Publication Profile
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Education
Prof. Jim Sheu’s educational journey laid a strong foundation for his impactful scientific career. He earned his Ph.D. in Life Science from the prestigious National Tsing-Hua University, Taiwan, in 2002 🧬. This doctoral training provided him with deep expertise in molecular biology, genetics, and biomedical research. Prior to that, he completed his B.S. in Biology from Fu-Jen University, Taiwan, in 1994 🧪. The rigorous academic environment at these institutions honed his critical thinking and experimental skills. His thesis and postdoctoral work involved advanced molecular techniques and translational research applications. With education deeply rooted in cellular biology and medical biotechnology, Prof. Sheu has seamlessly integrated his academic background with real-world research, evolving into a leading expert in cancer biology, stem cell therapies, and women’s health. His academic excellence has continued to inspire his students and collaborators across various institutes.
Experience
Prof. Sheu’s career spans academia, clinical research, and biotechnology. Since 2014, he has served as Professor at the Institute of Biomedical Sciences, National Sun Yat-sen University 🏫. Previously, he held multiple roles at China Medical University (2006–2014), including Researcher, Professor, Associate Professor, and Assistant Professor in the Graduate Institute of Chinese Medical Science 🧑🏫. His early international experience includes being a Research Fellow at Johns Hopkins Medical Institutions (2004–2006) 🔬. He also held leadership positions at Taiwan’s Development Center for Biotechnology (2003–2004), directing and managing key protein drug and biomedicine projects. His academic and research trajectory is marked by interdisciplinary innovation, integrating biomedical engineering, genetics, and pharmacology. Prof. Sheu’s deep involvement in translational research and collaborative initiatives underpins his reputation as a scientific leader in Taiwan and beyond.
Awards & Honors
Prof. Sheu has earned several prestigious honors celebrating his research excellence and innovation. In 2023, he was part of the award-winning Biomedical Team at National Sun Yat-sen University for a serum-free stem cell medium at the NBRP Pitch Day 🧫🏅. He also received the Outstanding Faculty of Basic Research award and the Tien-Te Lee Award for an outstanding poster on stem cell therapies for Parkinson’s disease. In 2022, he was honored by the Taiwan Endometriosis Society for his research using traditional medicine to modulate immune responses 🌿🧠. Additionally, he won the Prof. Chii-Ruey Tzeng Award for an impactful paper in endometriosis research. These accolades highlight Prof. Sheu’s interdisciplinary impact, bridging traditional Chinese medicine, molecular biology, and cutting-edge therapeutic development. His continuous recognition by scientific communities underscores his leadership in biomedical innovation.
Research Projects
Prof. Jim Sheu has actively contributed as a project reviewer in the field of life sciences since 2012 🌱. He serves the National Science and Technology Council (NSTC) in Taiwan and has reviewed projects for various institutions including Tri-Service General Hospital (2021–present), Kaohsiung Veterans General Hospital (2021–present), and Zuoying Armed Forces General Hospital (2020–present) 🏥. He also evaluated projects for National Tsing-Hua University (2023) and Kaohsiung Chang Gung Smart Hospital (2022) 🎓. His expertise has extended globally, reviewing for Italy’s Ministry of Health in 2015 🇮🇹 and South Africa’s Medical Research Council in 2012 🇿🇦, showcasing his international recognition 🌍.
Research Focus
Prof. Sheu’s research is centered on cancer biology, stem cell therapy, gynecological diseases, and translational medicine. He explores the molecular mechanisms of tumor progression, particularly in microsatellite instability and glioblastoma 🔍🧠. His investigations into ethnic-specific genetic markers for endometriosis and ovarian aging highlight his commitment to personalized medicine. Another focus lies in the regulation of immune responses using traditional herbal compounds, bridging modern molecular science with Eastern medicine 🌿🧪. He has led multi-omics studies that decode complex disease pathways, including mitochondrial dysfunction in breast cancer. Additionally, he is advancing serum-free stem cell enhancement technologies aimed at clinical application. Prof. Sheu’s interdisciplinary approach links genomics, proteomics, and pharmacology, translating basic research into viable therapeutic strategies. His work significantly contributes to understanding cellular aging, reproductive biology, and cancer therapy.
Publication Top Notes
Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma
Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma
A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival
Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells
Autophagy and its link to type II diabetes mellitus
Talin‐1 overexpression defines high risk for aggressive oral squamous cell carcinoma and promotes cancer metastasis
Kaempferol inhibits enterovirus 71 replication and internal ribosome entry site (IRES) activity through FUBP and HNRP proteins