Elie Azoulay | Medicine and Health Sciences | Hypothesis Achievement Award

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Prof. Elie Azoulay | Medicine and Health Sciences | Hypothesis Achievement Award 

Intensive care medicine department, at Saint Louis hospital, France.

Prof. Elie Azoulay is a distinguished French intensivist and the Director of the Critical Care Department at Hôpital Saint-Louis in Paris. He is renowned for his pioneering work in managing critically ill immunocompromised patients. As the founder and director of Nine-I, a multinational group focusing on immunocompromised patients, and co-director of the Famirea Study Group, he has significantly advanced research in intensive care medicine. His leadership extends to founding GRRR-OH, a French multicenter group dedicated to critically ill immunocompromised patients. Prof. Azoulay’s academic contributions are further highlighted by his role as Editor-in-Chief of Intensive Care Medicine from 2012 to 2018, during which the journal’s impact factor rose from 5 to 18. He has also served as President of the European Society of Intensive Care Medicine and is an advisory board member for The Lancet Respiratory Medicine.

Professional Profile

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🎓 Education

Prof. Azoulay’s academic journey began at Paris VI University (Sorbonne), where he earned his MD in 1991. He furthered his expertise with a Master’s degree in Respiratory Physiology from Paris XII University in 1995. In 2002, he completed his PhD in Respiratory Physiology at Paris VII University (Descartes). His commitment to advancing medical science led him to obtain Habilitation to Conduct and Lead Research from Paris VII University in 2003. Additionally, he holds a University Diploma in Critical Care Management of Immunocompromised Patients from Université Paris Cité, obtained in 2012. His educational background underscores his dedication to both clinical excellence and research innovation in intensive care medicine.

💼 Experience

Prof. Azoulay has an extensive career in intensive care medicine, beginning as a medical intern at Bichat-Claude Bernard Hospital in Paris. He has held significant positions, including serving as a professor of medicine at Paris VII University since 2004. His leadership roles encompass founding and directing several research groups, such as GRRR-OH and Nine-I, focusing on critically ill immunocompromised patients. He has been actively involved in various committees, including the Strategy Committee of the Hospital Group in Paris and the Medical Staffing Group. Prof. Azoulay’s editorial contributions are notable, having served as Editor-in-Chief of Intensive Care Medicine and as an associate editor for prominent journals like Critical Care Medicine and American Journal of Respiratory and Critical Care Medicine. His work has significantly influenced the field of intensive care medicine, particularly concerning immunocompromised patients.link.springer.com

🔬 Research Interests

Prof. Azoulay’s research primarily focuses on the management of critically ill immunocompromised patients, particularly those with hematological malignancies or undergoing immunosuppressive therapies. His work addresses acute respiratory failure, infections, and the psychosocial impact on patients and their families. He has led multicenter studies on the outcomes of intensive care in immunocompromised patients and the prevalence of ICU-related conflicts. His research also delves into the prevention of mental health disorders in ICU settings and the development of strategies to support family members of critically ill patients. Through his interdisciplinary approach, Prof. Azoulay aims to enhance patient care and outcomes in intensive care units.

🏆 Awards

Prof. Azoulay’s exceptional contributions to intensive care medicine have been recognized with several prestigious awards. In 2021, he received the International KJF Award, acknowledging his significant impact on critical care research. His editorial leadership has been instrumental in elevating the impact factor of Intensive Care Medicine. Additionally, his involvement in various international research initiatives has garnered him recognition from global medical communities. These accolades reflect his dedication to advancing the field of intensive care medicine and improving patient outcomes worldwide.rigshospitalet.dk

📚 Top Noted Publications

Prof. Azoulay has authored over 1,200 publications, contributing extensively to the field of intensive care medicine. Notable among his works is the 2019 study on acute respiratory failure in immunocompromised adults, published in The Lancet Respiratory Medicine, which has been cited over 1,000 times. His 2022 research in JAMA on post-traumatic stress symptoms in family members of ICU patients has also garnered significant attention. These publications reflect his commitment to addressing both clinical and psychosocial aspects of critical care. His work continues to influence practices and policies in intensive care units globally.

📌 1. Outcomes in Immunocompromised Patients with Acute Hypoxemic Respiratory Failure Treated by High-Flow Nasal Oxygen

Journal: Intensive Care Medicine
Date: April 2025
DOI: 10.1007/s00134-025-07890-5
Authors: Elie Azoulay, Mélanie Métais, Virginie Lemiale, Djamel Mokart, et al.
Summary:
This multicenter study evaluates the effectiveness and outcomes of high-flow nasal oxygen (HFNO) in immunocompromised patients with acute hypoxemic respiratory failure (AHRF). Key findings suggest that early initiation of HFNO is associated with improved survival, particularly in hematologic patients. It supports HFNO as a frontline noninvasive respiratory support strategy in this vulnerable population.

📌 2. Correction: HELLO – A Protocol for a Cluster RCT to Enhance ICU Team Cohesion

Journal: Intensive Care Medicine Experimental
Date: January 2025
DOI: 10.1186/s40635-024-00702-y
Authors: Elie Azoulay, Nancy Kentish Barnes, Sheila Nainan Myatra, et al.
Summary:
This correction addresses minor protocol amendments in the HELLO trial, aimed at improving interpersonal relationships and teamwork among ICU professionals. The original trial focuses on evaluating whether targeted interventions can reduce burnout and enhance job satisfaction, thus improving team-based care delivery.

📌 3. Lack of Up-to-Date Studies and Data Conversion May Lead to Biased Results: A Response to Wang et al.

Journal: Critical Care
Date: December 2024
DOI: 10.1186/s13054-024-05223-4
Authors: Ali Ait Hssain, Amir Vahedian-Azimi, Elie Azoulay, et al.
Summary:
A scholarly rebuttal to a prior publication, emphasizing the importance of timely and context-relevant data in intensive care research. The authors argue that reliance on outdated studies and improper data interpretation can introduce significant bias in clinical decision-making and policy formulation.

📌 4. Complement System Activation: Bridging Physiology, Pathophysiology, and Therapy

Journal: Intensive Care Medicine
Date: November 2024
DOI: 10.1007/s00134-024-07611-4
Authors: Elie Azoulay, Julien Zuber, Djillali Annane, et al.
Summary:
A comprehensive review of complement system activation in critically ill patients, exploring its dual role in host defense and inflammatory damage. The paper highlights novel therapeutic targets and the need for individualized modulation in conditions like sepsis and ARDS.

📌 5. Treatment of Invasive Pulmonary Aspergillosis and Candidiasis in ICU Patients

Journal: American Journal of Respiratory and Critical Care Medicine
Date: November 2024
DOI: 10.1164/rccm.202410-2045ST
Authors: Oleg Epelbaum, Elie Azoulay, et al.
Summary:
This ATS Clinical Practice Guideline outlines evidence-based recommendations for diagnosing and treating invasive fungal infections in ICU settings. It provides a framework for empirical and targeted antifungal therapy, addressing the rising concern of fungal superinfections in critical care.

Conclusion

Professor Elie Azoulay is an outstanding candidate for the Research for Hypothesis Achievement Award. His pioneering work in the intensive care management of immunocompromised patients, groundbreaking contributions to mental health in ICU survivors and their families, and leadership in multicenter, hypothesis-driven trials position him as a globally respected clinician-scientist. His profile aligns deeply with the intent of the award—translating complex hypotheses into high-impact, patient-centered outcomes.

Xianjuan Zhang | Medicine and Health Sciences | Best Researcher Award

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Ms. Xianjuan Zhang | Medicine and Health Sciences | Best Researcher Award 

Attending physician, at The Affiliated Hospital of Qingdao University, China.

Dr. Xianjuan Zhang is a rising virologist and clinical researcher at the Department of Clinical Laboratory, the Affiliated Hospital of Qingdao University. She earned her Ph.D. and M.Sc. in Pathogen Biology from Qingdao University, dedicating her academic career to investigating the pathogenic mechanisms of Human Cytomegalovirus (HCMV). With a strong foundation in virology, molecular biology, and immune evasion strategies, she has published impactful studies in top-tier journals, including Cellular and Molecular Gastroenterology and Hepatology, PLoS One, and Molecular Neurobiology. Dr. Zhang’s work provides novel insights into virus-host interactions and opens avenues for potential therapeutic interventions. Her research excellence is matched by her dedication to academic service as a peer reviewer for the International Journal of Molecular Sciences. With a strong command of advanced laboratory and bioinformatics tools, Dr. Zhang continues to contribute significantly to the understanding of viral pathogenesis. 📖🧫🔍

Professional Profile

Scopus

🎓 Education 

Dr. Xianjuan Zhang pursued both her doctoral and master’s degrees in Pathogen Biology at Qingdao University, China. During her M.Sc. (2016–2019), she developed a strong grasp of virology and immunology fundamentals, laying the groundwork for her more advanced research pursuits. Her Ph.D. studies (2019–2023) were marked by in-depth exploration of Human Cytomegalovirus (HCMV) and its impact on host cells, where she utilized in vivo and in vitro models to unravel molecular and immunological interactions. She mastered a wide range of technical tools including CRISPR, qPCR, siRNA knockdown, Western blotting, and bioinformatics analysis, which enabled her to investigate virus-host mechanisms at a molecular level. Her academic journey reflects not only deep theoretical understanding but also a practical orientation toward translational virology research. Her graduate education laid the foundation for a promising research career focused on infection, immunity, and molecular pathogenesis. 🎓🧪📘

🧑‍🔬 Experience 

Dr. Zhang has amassed valuable academic and professional experience centered on virology and molecular biology. Since 2023, she has served as a peer reviewer for the International Journal of Molecular Sciences, where she evaluates cutting-edge research on host-pathogen interactions, immune modulation, and therapeutic strategies. This role reflects her standing in the scientific community and her expertise in viral pathogenesis. In her research role at the Affiliated Hospital of Qingdao University, Dr. Zhang contributes to multidisciplinary projects aimed at understanding the cellular impact of Human Cytomegalovirus. She collaborates with pathologists, microbiologists, and molecular biologists, enhancing both the quality and translational potential of her research. Her work spans embryonic development, immune suppression, and metabolic syndromes linked to viral infections. Dr. Zhang’s collaborative and peer-reviewed experience demonstrates her capability to contribute both as a researcher and a reviewer in high-impact scientific contexts. 🧬🧫👩‍⚕️

🔬 Research Interests 

Dr. Zhang’s research revolves around the complex interplay between viruses and their hosts, with a primary focus on Human Cytomegalovirus (HCMV). Her studies explore how HCMV modulates host immune systems through evasion mechanisms, particularly focusing on the IL10/STAT3 pathway and antigen presentation suppression in macrophages. She is interested in decoding the molecular mechanisms by which viral proteins interfere with embryonic development, hepatic functions, and neurogenesis, using transgenic mouse models. In addition, Dr. Zhang investigates the role of the gut microbiome and viral infections in metabolic diseases such as hepatic steatosis and gestational diabetes. Her work seeks to identify novel therapeutic targets and enhance understanding of virus-induced pathologies. By leveraging molecular biology, immunological assays, and bioinformatics, Dr. Zhang’s research aims to bridge laboratory findings with clinical applications, offering potential advancements in diagnostics and treatment strategies for viral infections. 🦠🧠💉

🏅 Awards 

Dr. Xianjuan Zhang is a nominee for excellence in early-career virology research due to her impactful studies and commitment to scientific advancement. Although still in the early stages of her professional journey, her work has been published in high-impact journals and widely cited by the virology research community. Her contributions to understanding the effects of HCMV on organ development and immune regulation have positioned her as a promising voice in the field. She has been actively engaged in academic service through peer review, demonstrating leadership and responsibility in maintaining scientific integrity. Her nominations stem from both research merit and her application of science to solve critical health issues. With a portfolio of interdisciplinary studies connecting virology, immunology, and metabolic health, Dr. Zhang is a compelling candidate for any early-career research excellence awards. 🏆📚🧪

📚 Top Noted Publications

Dr. Zhang has authored and co-authored several impactful research papers on Human Cytomegalovirus and its pathological mechanisms. Her publication record demonstrates a consistent focus on viral interference with host systems:

1. Zhang X., et al. (2022)

Title: Human Cytomegalovirus-IE2 Affects Embryonic Liver Development and Survival in Transgenic Mouse
Journal: Cellular and Molecular Gastroenterology and Hepatology
Volume: 14(2), Pages: 494–511
DOI: 10.1016/j.jcmgh.2022.01.002
Cited by: 14
Summary: This study investigates the effects of the human cytomegalovirus (HCMV) immediate-early protein 2 (IE2) on embryonic liver development. Using a transgenic mouse model, the researchers demonstrate that IE2 impairs hepatic development, leading to increased embryonic mortality, likely due to disrupted hepatocyte differentiation and survival mechanisms.

2. Zhang X., et al. (2025)

Title: HCMV-IE2 suppresses antigen presentation via IL10/STAT3 pathway
Journal: PLoS One
Volume: 20(5), Article ID: e0322334
DOI: 10.1371/journal.pone.0322334
Cited by: 3
Summary: This paper describes how HCMV-IE2 modulates host immune responses. Specifically, it shows that IE2 inhibits antigen presentation by upregulating IL-10 and activating the STAT3 signaling pathway, leading to immune evasion. This mechanism could contribute to persistent infection and immune suppression.

3. Niu D., Zhang X., et al. (2023)

Title: IE2 disrupts neural progenitor development
Journal: Molecular Neurobiology
Volume: 60(7), Pages: 3883–3897
DOI: 10.1007/s12035-023-03348-2
Cited by: 5
Summary: This study explores the neurodevelopmental impact of HCMV-IE2, showing that IE2 expression disrupts neural progenitor cell proliferation and differentiation. The findings suggest a molecular basis for HCMV-related neurodevelopmental disorders in congenital infections.

4. Zhou X., Zhang X., et al. (2023)

Title: Gut microbiota induces hepatic steatosis
Journal: Scientific Reports
Volume: 13(1), Article ID: 6701
DOI: 10.1038/s41598-023-33829-4
Cited by: 8
Summary: This article investigates the role of gut microbiota in liver fat accumulation. It finds that alterations in microbial composition can induce hepatic steatosis in mice, potentially via modulation of metabolic and inflammatory pathways. Zhang X.’s contribution adds insights into host-microbiome interactions and liver health.

5. Wang Y., Zhang X., et al. (2022)

Title: HCMV and gestational diabetes
Journal: PeerJ
Volume: 10, Article ID: e1293
DOI: 10.7717/peerj.1293
Cited by: 6
Summary: This study explores the association between HCMV infection and gestational diabetes mellitus (GDM). The authors suggest a potential link between HCMV-induced immune dysregulation and glucose intolerance during pregnancy, providing new insight into viral contributions to metabolic disorders.

Conclusion 

Dr. Xianjuan Zhang is a promising early-career researcher whose focused contributions to HCMV pathogenesis and host interactions are impactful and published in high-quality journals. Her technical capabilities, publication record, and reviewer role indicate a high level of scientific maturity for her career stage.