Prof. Dr Panagiotis Liakos, Faculty of Medicine, University of Thessaly, Greece
Prof. Dr. Panagiotis Liakos is an esteemed biochemist and researcher specializing in cellular biochemistry and hypoxia-related cancer mechanisms. He earned his Maîtrise, Master’s, and Ph.D. in Molecular and Cellular Biology from Joseph Fourier I University, France. His postdoctoral work at Aristotle University in Greece laid the foundation for his academic career, leading him to his current role as Professor and Director of the Department of Basic and Applied Biomedical Sciences at the University of Thessaly. His research focuses on hypoxia-inducible factors (HIFs), particularly HIF-2α, exploring its role in cancer and angiogenesis. 🧬👨🔬📚
Publication Profile
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Education
Prof. Dr. Panagiotis Liakos is a distinguished biochemist with a career spanning from Grenoble to Greece. He completed a Maîtrise in Biochemistry (1994) and a Master’s in Molecular and Cellular Biology (1995) at Joseph Fourier I University, France, followed by a PhD (1999) in Biochemistry and Cellular Endocrine Regulation. His postdoctoral research was conducted at Aristotle University Thessaloniki. In 2003, he became a Lecturer at the University of Thessaly, advancing to Professor in 2022. Currently, he leads the Department of Basic and Applied Biomedical Sciences. His clinical expertise includes years at Larissa University Hospital. 🌍🔬📚👨🔬💼
Research Project
Prof. Dr. Panagiotis Liakos has significantly contributed to pioneering health research. Highlights include leading the French Ministry of Health’s 1994 Breast Cancer Prevention program, advancing studies on ACTH receptor expression in adrenal glands (1995-1998), and collaborating on a French-Portuguese program to analyze steroidogenic enzymes in rats and adrenal carcinomas. Furthering adrenal cancer research, he partnered with the Fondation pour la Recherche Médicale (1998-1999). Dr. Liakos explored metalloproteases in skin pathophysiology in a Greek program (2001-2003) and obesity rates in Thessaly (2005-06). His work on signaling pathways under hypoxic stress enriches endocrine research. 🧬🔬
Experience
Prof. Dr. Panagiotis Liakos has been a dedicated educator and coordinator in molecular biology, genetics, and biochemistry since 2001. He taught Biochemistry I & II and Clinical Biochemistry at Democritus University of Thrace, later joining the University of Thessaly to instruct Molecular Biology, Metabolism Regulation, and various biochemistry courses. Since 2004, he has led the Clinical Biochemistry course for medical students and coordinated the Cellular Signaling course in molecular medicine. His teaching repertoire includes postgraduate courses on reproduction genetics, human genetics, and balanced nutrition. Prof. Liakos’s commitment to education spans two decades, fostering expertise in health sciences. 📘🧬👨🏫✨
Honors
Prof. Dr. Panagiotis Liakos has been recognized internationally for his research achievements, receiving prestigious scholarships and fellowships from the French Ministry of Research and Fondation pour la Recherche Médicale. These honors underscore his dedication and impactful contributions to his field, highlighting the global relevance of his work. Through these awards, Dr. Liakos has advanced his research, fostering significant progress and collaboration. His achievements not only emphasize his scientific expertise but also reflect his commitment to excellence in research and innovation. 🌍📚🔬
Research Focus
Prof. Dr. Panagiotis Liakos specializes in cellular and molecular biology, particularly focusing on hypoxia and its effects on cellular processes. His research explores how hypoxia-inducible factors (HIFs), especially HIF-1 and HIF-2, regulate gene expression under low-oxygen conditions and influence cancer progression, lipid metabolism, and viral replication. Dr. Liakos’s work also examines the effects of oxidative stress and signaling pathways like PI-3K and MAPK on cellular adaptation to hypoxic stress. His contributions are significant in understanding hypoxia’s role in disease states such as cancer and liver disease, and its broader implications for therapeutic development. 🧬🩺🔬🌬️📊
Publication Top Notes
Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression
Cobalt induces hypoxia-inducible factor-1α (HIF-1α) in HeLa cells by an iron-independent, but ROS-, PI-3K-and MAPK-dependent mechanism
Bortezomib represses HIF-1α protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells
The role of hypoxia‐inducible factor‐2 alpha in angiogenesis
Cushing’s syndrome due to a gastric inhibitory polypeptide-dependent adrenal adenoma: insights into hormonal control of adrenocortical tumorigenesis
Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells