Prof Dr Zsuzsanna Izsvak, Max Delbruck Center for Molecular Medicine, Germany
Dr. Zsuzsanna Izsvák is a distinguished geneticist and the Permanent Group Leader of Mobile DNA at Max-Delbrück-Center in Berlin, Germany. Renowned for her pioneering work on the Sleeping Beauty transposon system 🧬, she has revolutionized gene therapy and genome engineering. With over 17,000 citations and an H-index of 67 📚, her research spans transposon-based genome manipulations, stem cell technology, and translational applications in cancer and gene therapy. Awarded the European Young Investigator Award, ERC Advanced Grants, and nominated for a Nobel Prize 🏆, Dr. Izsvák’s innovative contributions have had a profound impact on modern genetics.
Publiucation profile
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Education
In 1994, He earned my Ph.D. in Biology from the Hungarian Academy of Sciences. My post-doctoral journey included prestigious institutions such as the University of Minnesota and the Netherlands Cancer Institute in Amsterdam, NL. From 1991 to 1997, he served at the Hungarian Academy of Sciences, and from 1997 to 1999, He continued my research at the Medical University of Debrecen in Hungary. In 2011, He was recognized as an EMBO fellow and awarded a DSc. My academic focus has spanned Genetics, Molecular Biology, Molecular Genetics, and Human Genetics, culminating in my current role as a Professor 👩🔬📚🔬.
Honors
Dr Zsuzsanna Izsvak, a distinguished scientist in molecular biology, has garnered numerous accolades throughout a prolific career. Notable milestones include receiving the Excellence Award from the Hungarian Academy of Sciences in 1990 🏆, an EMBO long-term postdoctoral fellowship in 1996 🌍, and the prestigious EURYI European Young Investigator Award in 2004 🌟. Their groundbreaking work on SB100X earned them international acclaim, including the SB100X Molecule of the Year in 2009 and recognition from the European Society of Gene and Cell Therapy. Nominated for a Nobel Prize in 2011, Dr. Zsuzsanna Izsvak continues to shape research, notably with ERC Advanced grants and leadership roles in scientific committees. Elected as a foreign member of the Hungarian Academy of Sciences in 2019, they now serve as President of the Dennis Gabor Gesellschaft since 2023 🌐.
Research focus
Based on their research focus, the authors primarily delve into the molecular characteristics, evolution, and applications of transposable elements (TEs), particularly the Sleeping Beauty (SB) transposon. Their work spans from fundamental studies elucidating the structural and functional domains of TEs to pioneering applications in genetic manipulation across vertebrate species, including humans. They explore how TEs like SB can be harnessed as genetic tools for stable gene transfer and long-term transgene expression, highlighting their potential in molecular therapy and genome engineering. This research is crucial for understanding TE biology and exploiting their utility in biotechnological and biomedical contexts. 🧬🔬
Publication top notes
Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells
Ten things you should know about transposable elements
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates
Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system
Resident aliens: the Tc1/mariner superfamily of transposable elements
Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates
Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells
Gibbon genome and the fast karyotype evolution of small apes
Transposon-mediated genome manipulation in vertebrates
Progress and prospects in rat genetics: a community view